Mc Adams rose to fame in 2004 with her roles in the comedy Mean Girls and the romantic drama The Notebook.
In 2005, she starred in the romantic comedy Wedding Crashers, the psychological thriller Red Eye, and the family comedy-drama The Family Stone.
Afterwards, Mc Adams starred opposite Cillian Murphy in Wes Craven's psychological thriller Red Eye, where she played a young hotel manager who is held captive by Murphy's character while aboard a red-eye flight.
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"Truthfully, I never really wanted to be a big movie star.
I never even wanted to work outside of Canada, or outside of the theatre." Mc Adams returned to her film career in 2008.
In 2015, her highest profile roles were in the second season of the HBO crime drama True Detective, and as journalist Sacha Pfeiffer in the drama Spotlight.
For her performance in Spotlight, she was nominated for the Academy Award for Best Supporting Actress.
She was hailed by the media as Hollywood's new "it girl", and received a BAFTA nomination for Best Rising Star.